For research use only. Not for therapeutic Use.
Lapaquistat acetate（Cat No.:R013101）, is a synthetic compound related to the statin class of drugs. Statins are widely used to lower cholesterol levels in the treatment of hypercholesterolemia and the prevention of cardiovascular diseases. Lapaquistat acetate was developed as a cholesterol-lowering medication, specifically targeting the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, which plays a key role in cholesterol synthesis.
| Catalog Number | R013101 |
| CAS Number | 189060-13-7 |
| Synonyms | 1-[2-[(3R,5S)-1-[3-(Acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-4-piperidineacetic Acid; ?(3R-trans)-1-[[1-[3-(acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)- |
| Molecular Formula | C33H41ClN2O9 |
| Purity | ≥95% |
| Target | Squalene Synthase Inhibitor |
| Storage | Store at -20°C |
| Overview of Clinical Research | Lapaquistat acetate is a squalene synthase inhibitor used to treat hyperlipidaemia. |
| IUPAC Name | 2-[1-[2-[(3R,5S)-1-(3-acetyloxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-5H-4,1-benzoxazepin-3-yl]acetyl]piperidin-4-yl]acetic acid |
| InChI | InChI=1S/C33H41ClN2O9/c1-20(37)44-19-33(2,3)18-36-25-10-9-22(34)16-24(25)30(23-7-6-8-26(42-4)31(23)43-5)45-27(32(36)41)17-28(38)35-13-11-21(12-14-35)15-29(39)40/h6-10,16,21,27,30H,11-15,17-19H2,1-5H3,(H,39,40)/t27-,30-/m1/s1 |
| InChIKey | CMLUGNQVANVZHY-POURPWNDSA-N |
| SMILES | CC(=O)OCC(C)(C)CN1C2=C(C=C(C=C2)Cl)C(OC(C1=O)CC(=O)N3CCC(CC3)CC(=O)O)C4=C(C(=CC=C4)OC)OC |
| Reference | <br /> |
