Lapatinib-d7 Ditosylate

• CAT Number: R050134
• CAS Number: 1009307-24-7
• Molecular Formula: C36H34ClFN4O7S2
• Molecular Weight: 760.3
• Purity: ≥95%
• Synonyms: N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl-d7]amino]methyl]-2-furanyl]-4-quinazolinamine Bis(4-methylbenzenesulfonate) Ditosylate; GW-572016F-d7 Ditosylate; Tykerb-d7 Ditosylate
• Storage: Store at -20°C
• IUPAC Name: N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[1,1,2,2-tetradeuterio-2-(trideuteriomethylsulfonyl)ethyl]amino]methyl]furan-2-yl]quinazolin-4-amine;4-methylbenzenesulfonic acid
• InChI: InChI=1S/C29H26ClFN4O4S.C7H8O3S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19;1-6-2-4-7(5-3-6)11(8,9)10/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35);2-5H,1H3,(H,8,9,10)/i1D3,11D2,12D2
• InChIKey: OZDXXJABMOYNGY-LXACFCGFSA-N
• SMILES: [2H]C([2H])([2H])S(=O)(=O)C([2H])([2H])C([2H])([2H])NCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl.CC1=CC=C(C=C1)S(=O)(=O)O

Lapatinib-d7 Ditosylate is a deuterated form of Lapatinib, a dual tyrosine kinase inhibitor that targets the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), both of which are involved in the growth and proliferation of cancer cells. The deuterium atoms in Lapatinib-d7 enhance its stability, making it particularly useful in pharmacokinetic studies, where it allows for more precise tracking of the drug’s absorption, distribution, metabolism, and excretion. This compound is essential in pharmaceutical research, especially in the development of targeted therapies for cancers such as breast cancer, and in studies within the fields of medicinal and organic chemistry.