For research use only. Not for therapeutic Use.
Lapatinib Ditosylate (Cas.No:388082-78-8), also known by its brand names Tykerb, Tyverb, and GW-572016, is a tyrosine kinase inhibitor used in the treatment of certain types of breast cancer. It works by blocking the signaling pathways of the human epidermal growth factor receptor 2 (HER2) and epidermal growth factor receptor (EGFR), helping to inhibit cancer cell growth and proliferation.
| Catalog Number | I011591 |
| CAS Number | 388082-78-8 |
| Synonyms | N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine;4-methylbenzenesulfonic acid;hydrate |
| Molecular Formula | C29H26ClFN4O4S.2C7H8O3S.H2O |
| Purity | ≥95% |
| Target | Protein Tyrosine Kinase/RTK |
| Solubility | >24.3mg/mL in DMSO |
| Storage | Store at RT |
| Related CAS | 388082-77-7 |
| IUPAC Name | N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine;4-methylbenzenesulfonic acid;hydrate |
| InChI | InChI=1S/C29H26ClFN4O4S.2C7H8O3S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19;2*1-6-2-4-7(5-3-6)11(8,9)10/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35);2*2-5H,1H3,(H,8,9 |
| InChIKey | UWYXLGUQQFPJRI-UHFFFAOYSA-N |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl |
