Lappaconitine hydrobromide

• CAT Number: I005719
• CAS Number: 97792-45-5
• Molecular Formula: C32H44N2O8.HBr
• Molecular Weight: 665.61
• Purity: ≥95%
• Solubility: 10 mM in DMSO
• Storage: 3 years -20C powder

Lappaconitine hydrobromide, a diterpene alkaloid, is a drug for the treatment of cardiac arrhythmias.

In vitro: Lappaconitine hydrobromide was found to exert an inhibitory effect on inward tetrodotoxin-sensitive sodium currents without changing their voltage dependence.

Reference

[1]. A. E. Valeev, et al. Effects of allapinine on sodium currents in neurons isolated from the rat trigeminal ganglion and cardiomyocytes. Neurophysiology, 1990, 22 (2): 157-162. 


[2]. Vakhitova IuV, et al. To the mechanisms of antiarrhythmic action of Allapinine. Bioorg Khim, 2013, 39 (1):105-16 


[3]. Abdalla A., et al. Allapinine pharmacodynamics and potential adverse effects. Kardiologiya. 29(7): 29-32