Largazole

• CAT Number: I030503
• CAS Number: 1009815-87-5
• Molecular Formula: C29H42N4O5S3
• Molecular Weight: 622.85
• Purity: 98%
• Synonyms: Largazole
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: S-((E)-4-((12Z,22Z,24R,5S,8S)-5-isopropyl-24-methyl-3,6,10-trioxo-24,25-dihydro-7-oxa-4,11-diaza-1(4,2),2(2,4)-dithiazolacyclododecaphane-8-yl)but-3-en-1-yl) octanethioate
• InChI: InChI=1S/C29H42N4O5S3/c1-5-6-7-8-9-13-24(35)39-14-11-10-12-20-15-22(34)30-16-23-31-21(17-40-23)26-33-29(4,18-41-26)28(37)32-25(19(2)3)27(36)38-20/h10,12,17,19-20,25H,5-9,11,13-16,18H2,1-4H3,(H,30,34)(H,32,37)/b12-10+/t20-,25+,29+/m1/s1
• InChIKey: AXESYCSCGBQJBL-SZPBEECKSA-N
• SMILES: O=C([C@H](C(C)C)NC([C@@]1(C)N=C(SC1)c2csc(CN3)n2)=O)O[C@H](/C=C/CCSC(CCCCCCC)=O)CC3=O

Largazole is a potent and selective histone deacetylase (HDAC) inhibitor. It is also an antiproliferative agent from Symploca.

Reference

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