Largazole

• CAT Number: I030503
• CAS Number: 1009815-87-5
• Molecular Formula: C29H42N4O5S3
• Molecular Weight: 622.85
• Purity: 98%
• Synonyms: Largazole
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: S-((E)-4-((12Z,22Z,24R,5S,8S)-5-isopropyl-24-methyl-3,6,10-trioxo-24,25-dihydro-7-oxa-4,11-diaza-1(4,2),2(2,4)-dithiazolacyclododecaphane-8-yl)but-3-en-1-yl) octanethioate
• InChI: InChI=1S/C29H42N4O5S3/c1-5-6-7-8-9-13-24(35)39-14-11-10-12-20-15-22(34)30-16-23-31-21(17-40-23)26-33-29(4,18-41-26)28(37)32-25(19(2)3)27(36)38-20/h10,12,17,19-20,25H,5-9,11,13-16,18H2,1-4H3,(H,30,34)(H,32,37)/b12-10+/t20-,25+,29+/m1/s1
• InChIKey: AXESYCSCGBQJBL-SZPBEECKSA-N
• SMILES: O=C([C@H](C(C)C)NC([C@@]1(C)N=C(SC1)c2csc(CN3)n2)=O)O[C@H](/C=C/CCSC(CCCCCCC)=O)CC3=O

Largazole(CAT: I030503) is a potent and selective histone deacetylase (HDAC) inhibitor, derived from a marine cyanobacterium. Known for its strong antiproliferative activity, Largazole is widely utilized in epigenetic research, particularly in the study of cancer and other diseases involving aberrant gene expression. By inhibiting HDACs, it promotes histone acetylation, leading to altered transcriptional regulation and cell cycle arrest in cancer cells. With its high specificity and efficacy, Largazole serves as a valuable tool for investigating HDAC-mediated pathways, epigenetic modifications, and therapeutic strategies targeting histone deacetylation. Its stability and reliability make it ideal for both biochemical and cellular studies.