Larotaxel

For research use only. Not for therapeutic Use.

  • CAT Number: R046723
  • CAS Number: 156294-36-9
  • Molecular Formula: C₄₅H₅₃NO₁₄
  • Molecular Weight: 831.90
  • Purity: ≥95%
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Larotaxel (Cat No.: R046723) is a novel taxane-based chemotherapy drug, designed to target and inhibit microtubule dynamics, thereby interfering with cell division. It stabilizes microtubules, preventing their disassembly, which disrupts mitosis and leads to cancer cell apoptosis. Larotaxel has been evaluated in clinical trials for the treatment of various cancers, including non-small cell lung cancer, breast cancer, and prostate cancer. Its advantage over other taxanes lies in its improved solubility and effectiveness against tumors resistant to traditional chemotherapy agents.


CAS Number 156294-36-9
Synonyms

(αR,βS)-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxybenzenepropanoic Acid (1S,2S,4S,7R,8aR,9aS,10aR,12aS,12bR)-7,12a-Bis(acetyloxy)-1-(benzoyloxy)-1,3,4,7,8,9,9a,10,10a,12,12a,12b-dodecahydro-2-hydroxy-5,13,13-trimethyl-8-oxo-2,6-methano-2H-cycl

Molecular Formula C₄₅H₅₃NO₁₄
Purity ≥95%
Target Apoptosis
Storage -20°C
IUPAC Name [(1S,2S,3R,4S,7R,9S,11R,13R,16S)-4,13-diacetyloxy-1-hydroxy-16-[(2R,3S)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]oxy-15,18,18-trimethyl-12-oxo-6-oxapentacyclo[12.3.1.03,11.04,7.09,11]octadec-14-en-2-yl] benzoate
InChI 1S/C45H53NO14/c1-23-29(57-39(52)33(49)32(26-15-11-9-12-16-26)46-40(53)60-41(4,5)6)21-45(54)37(58-38(51)27-17-13-10-14-18-27)35-43(36(50)34(56-24(2)47)31(23)42(45,7)8)20-28(43)19-30-44(35,22-55-30)59-25(3)48/h9-18,28-30,32-35,37,49,54H,19-22H2,1-8H3,(H,46,53)/t28-,29+,30-,32+,33-,34-,35+,37+,43-,44+,45-/m1/s1
InChIKey DXOJIXGRFSHVKA-BZVZGCBYSA-N
SMILES CC1=C2[C@H](C(=O)[C@]34C[C@H]3C[C@@H]5[C@]([C@H]4[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C6=CC=CC=C6)NC(=O)OC(C)(C)C)O)O)OC(=O)C7=CC=CC=C7)(CO5)OC(=O)C)OC(=O)C

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