For research use only. Not for therapeutic Use.
LAS101057 is a potent, selective, and orally efficacious A2B receptor antagonist.
At 3 mg/kg, LAS101057 is active in preventing Acetyl-β-methylcholine-induced AHR, and at 10 mg/kg it inhibits AHR to Acetyl-β-methylcholine to a level virtually equal to that seen with Hexadecadrol at 1 mg/kg[1].
| Catalog Number | I006840 |
| CAS Number | 925676-48-8 |
| Synonyms | N-[5-(3-fluoropyridin-4-yl)-6-pyridin-3-ylpyrazin-2-yl]cyclopropanecarboxamide |
| Molecular Formula | C18H14FN5O |
| Purity | ≥95% |
| InChI | InChI=1S/C18H14FN5O/c19-14-9-21-7-5-13(14)17-16(12-2-1-6-20-8-12)23-15(10-22-17)24-18(25)11-3-4-11/h1-2,5-11H,3-4H2,(H,23,24,25) |
| InChIKey | XUYURJQIMYCWBB-UHFFFAOYSA-N |
| SMILES | C1CC1C(=O)NC2=CN=C(C(=N2)C3=CN=CC=C3)C4=C(C=NC=C4)F |
| Reference | [1]. Paul Eastwood, et al. Discovery of LAS101057: A Potent, Selective, and Orally Efficacious A2B Adenosine Receptor Antagonist. ACS Med Chem Lett. 2011 Mar 10; 2(3): 213-218. |
