For research use only. Not for therapeutic Use.
LAS38096 is a potent, selective, and efficacious A2B adenosine receptor antagonist.
| Catalog Number | I006842 |
| CAS Number | 851371-22-7 |
| Synonyms | LAS38096; LAS 38096; LAS-38096.;4-furan-2-yl-N-pyridin-3-yl-5-pyrimidin-4-ylpyrimidin-2-amine |
| Molecular Formula | C17H12N6O |
| Purity | ≥95% |
| Target | Adenosine Receptor |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4°C for short term or -20 °C for long term |
| IUPAC Name | 4-(furan-2-yl)-N-pyridin-3-yl-5-pyrimidin-4-ylpyrimidin-2-amine |
| InChI | InChI=1S/C17H12N6O/c1-3-12(9-18-6-1)22-17-20-10-13(14-5-7-19-11-21-14)16(23-17)15-4-2-8-24-15/h1-11H,(H,20,22,23) |
| InChIKey | YRPIMMMBNUUYLG-UHFFFAOYSA-N |
| SMILES | C1=CC(=CN=C1)NC2=NC=C(C(=N2)C3=CC=CO3)C4=NC=NC=C4 |
| Reference | 1:J Med Chem. 2007 May 31;50(11):2732-6. Epub 2007 May 1. Discovery and characterization of 4/’-(2-furyl)-N-pyridin-3-yl-4,5/’-bipyrimidin-2/’-amine (LAS38096), a potent, selective, and efficacious A2B adenosine receptor antagonist.Vidal B,Nueda A,Esteve C,Domenech T,Benito S,Reinoso RF,Pont M,Calbet M,López R,Cadavid MI,Loza MI,Cárdenas A,Godessart N,Beleta J,Warrellow G,Ryder H, PMID: 17469811 DOI: 10.1021/jm061333v </br><span>Abstract:</span> A novel series of N-heteroaryl 4/’-(2-furyl)-4,5/’-bipyrimidin-2/’-amines has been identified as potent and selective A(2B) adenosine receptor antagonists. In particular, compound 5 showed high affinity for the A(2B) receptor (Ki = 17 nM), good selectivity (IC(50): A(1) > 1000 nM, A(2A) > 2500 nM, A3 > 1000 nM), displayed a favorable pharmacokinetic profile in preclinical species, and showed efficacy in functional in vitro models. |
