For research use only. Not for therapeutic Use.
LAS38096（Cat No.:I006842）is a selective inhibitor of the protein kinase C (PKC) family, particularly targeting PKCβ. PKCβ plays a crucial role in regulating various cellular processes, including cell growth, differentiation, and inflammation. Inhibiting this enzyme can help modulate signaling pathways involved in conditions like cancer, autoimmune diseases, and cardiovascular disorders. LAS38096 has been investigated for its potential therapeutic applications in these areas by reducing abnormal cell proliferation and inflammation. It is being explored in preclinical studies for its role in managing diseases where PKCβ is dysregulated or overactive.
| Catalog Number | I006842 |
| CAS Number | 851371-22-7 |
| Synonyms | LAS38096; LAS 38096; LAS-38096.;4-furan-2-yl-N-pyridin-3-yl-5-pyrimidin-4-ylpyrimidin-2-amine |
| Molecular Formula | C17H12N6O |
| Purity | ≥95% |
| Target | Adenosine Receptor |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4°C for short term or -20 °C for long term |
| IUPAC Name | 4-(furan-2-yl)-N-pyridin-3-yl-5-pyrimidin-4-ylpyrimidin-2-amine |
| InChI | InChI=1S/C17H12N6O/c1-3-12(9-18-6-1)22-17-20-10-13(14-5-7-19-11-21-14)16(23-17)15-4-2-8-24-15/h1-11H,(H,20,22,23) |
| InChIKey | YRPIMMMBNUUYLG-UHFFFAOYSA-N |
| SMILES | C1=CC(=CN=C1)NC2=NC=C(C(=N2)C3=CC=CO3)C4=NC=NC=C4 |
| Reference | 1:J Med Chem. 2007 May 31;50(11):2732-6. Epub 2007 May 1. Discovery and characterization of 4/’-(2-furyl)-N-pyridin-3-yl-4,5/’-bipyrimidin-2/’-amine (LAS38096), a potent, selective, and efficacious A2B adenosine receptor antagonist.Vidal B,Nueda A,Esteve C,Domenech T,Benito S,Reinoso RF,Pont M,Calbet M,López R,Cadavid MI,Loza MI,Cárdenas A,Godessart N,Beleta J,Warrellow G,Ryder H, PMID: 17469811 DOI: 10.1021/jm061333v </br><span>Abstract:</span> A novel series of N-heteroaryl 4/’-(2-furyl)-4,5/’-bipyrimidin-2/’-amines has been identified as potent and selective A(2B) adenosine receptor antagonists. In particular, compound 5 showed high affinity for the A(2B) receptor (Ki = 17 nM), good selectivity (IC(50): A(1) > 1000 nM, A(2A) > 2500 nM, A3 > 1000 nM), displayed a favorable pharmacokinetic profile in preclinical species, and showed efficacy in functional in vitro models. |
