LASV inhibitor 3.3

• CAT Number: I030527
• CAS Number: 554438-52-7
• Molecular Formula: C30H37N3O2
• Molecular Weight: 471.63
• Purity: ≥95%
• Synonyms: N-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl]adamantane-1-carboxamide
• InChI: InChI=1S/C30H37N3O2/c34-27(21-31-29(35)30-18-22-15-23(19-30)17-24(16-22)20-30)32-11-13-33(14-12-32)28(25-7-3-1-4-8-25)26-9-5-2-6-10-26/h1-10,22-24,28H,11-21H2,(H,31,35)
• InChIKey: CUSOKWBOIRFXDP-UHFFFAOYSA-N
• SMILES: C1CN(CCN1C(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)CNC(=O)C45CC6CC(C4)CC(C6)C5

LASV inhibitor 3.3 is a Lassa fever virus (LASV) inhibitor. LASV inhibitor 3.3 binds with LASV glycoprotein (GP) and promotes virus membrane fusion and infection. LASV inhibitor 3.3 can be used for LASV infection research[1].
LASV inhibitor 3.3 (1 nM-100 μM; 1 h) inhibits transduction by murine leukemia virus (MLV) pseudotyped with the indicated viral glycoproteins with an IC50 value of 1.8 μM[1].
LASV inhibitor 3.3 (1 and 10 μM; 1 h) inhibits LAMP1 binding to LASV GP in vitro[1].

Reference

[1]. Wang MK, et al. Critical role for cholesterol in Lassa fever virus entry identified by a novel small molecule inhibitor targeting the viral receptor LAMP1. PLoS Pathog. 2018 Sep 28;14(9):e1007322.