Lathosterol

• CAT Number: R053043
• CAS Number: 80-99-9
• Molecular Formula: C27H46O
• Molecular Weight: 386.664
• Purity: ≥95%
• Synonyms: (3β,5α)-Cholest-7-en-3-ol; 5α-Cholest-7-en-3β-ol; 3β-Hydroxy-5α-cholest-7-ene; 7-En-3-cholestanol; Cholest-7-en-3-ol; Lathosterol; Δ7-Cholestenol; γ-Cholestenol
• Target: Endogenous Metabolite
• Storage: -20°C
• IUPAC Name: (3S,5S,9R,10S,13R,14R,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
• InChI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1
• InChIKey: IZVFFXVYBHFIHY-SKCNUYALSA-N
• SMILES: CC(C)CCCC(C)C1CCC2C1(CCC3C2=CCC4C3(CCC(C4)O)C)C

Lathosterol is an intermediate in the biosynthesis of cholesterol, formed during the conversion of lanosterol to cholesterol in the mevalonate pathway. It serves as a biomarker for cholesterol synthesis, with elevated levels indicating increased endogenous cholesterol production. Lathosterol is used in clinical and biochemical studies to assess the rate of cholesterol synthesis in the body, particularly in research focused on lipid metabolism, cardiovascular diseases, and the effects of cholesterol-lowering therapies like statins. Its role in the cholesterol biosynthesis pathway makes it a key molecule in understanding cholesterol homeostasis and related disorders.