For research use only. Not for therapeutic Use.
Lauformine (Cat No.: I030539) is a biguanide-class antidiabetic agent known for its blood glucose-lowering effects, similar to metformin. It reduces hepatic glucose production and improves insulin sensitivity without significantly increasing insulin secretion. Lauformine was studied for the treatment of type 2 diabetes but has limited clinical use due to concerns about lactic acidosis and safety compared to other biguanides. Though no longer widely used, Lauformine remains of interest in pharmacological research exploring the mechanisms of biguanide action and metabolic regulation in diabetes management.
| CAS Number | 91177-60-5 |
| Synonyms | Lauformine; |
| Molecular Formula | C17H21NO3 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | (1r,2a'R,4R)-2a',3',4',5'-tetrahydro-2'H-spiro[cyclohexane-1,1'-cyclopenta[ij][1,3]dioxolo[4,5-g]isoquinolin]-4-ol |
| InChI | InChI=1S/C17H21NO3/c19-11-1-4-17(5-2-11)8-12-14-10(3-6-18-12)7-13-16(15(14)17)21-9-20-13/h7,11-12,18-19H,1-6,8-9H2/t11-,12-,17-/m1/s1 |
| InChIKey | KWWQMZNQWSVKHN-PSTGCABASA-N |
| SMILES | O[C@H]1CC[C@]2(C3=C4[C@](C2)([H])NCCC4=CC5=C3OCO5)CC1 |
| Reference | 1: Mukhtar MR, Aziz AN, Thomas NF, Hadi AH, Litaudon M, Awang K. Grandine A, a new proaporphine alkaloid from the bark of Phoebe grandis. Molecules. 2009 Mar 23;14(3):1227-33. doi: 10.3390/molecules14031227. PubMed PMID: 19325519. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
