For research use only. Not for therapeutic Use.
Laurolitsine hydrochloride is an alkaloid isolated from Phoebe formosana, and shows weak anti-inflammatory activity.
Laurolitsine shows weak anti-inflammatory activity against NO production in RAW 267.4 and BV-2 cells[1]. Boldine, laurolitsine and litebamine (300 μM) remarkedly inhibit the aggregation of rabbit platelets induced by arachidonic acid (100 μM) and collagen (10 μM/mL), and slightly inhibit that induced by ADP (20 μM)[2].
| Catalog Number | I013436 |
| Synonyms | (6aS)-1,10-dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol;hydrochloride |
| Molecular Formula | C18H20ClNO4 |
| Purity | ≥95% |
| InChI | InChI=1S/C18H19NO4.ClH/c1-22-15-8-11-10(7-13(15)20)5-12-16-9(3-4-19-12)6-14(21)18(23-2)17(11)16;/h6-8,12,19-21H,3-5H2,1-2H3;1H/t12-;/m0./s1 |
| InChIKey | VJXHOVAEZCDLEW-YDALLXLXSA-N |
| SMILES | COC1=C(C=C2CC3C4=C(C2=C1)C(=C(C=C4CCN3)O)OC)O.Cl |
| Reference | [1]. Zhang SY, et al. [Alkaloids from roots and stems of Litsea cubeba]. Zhongguo Zhong Yao Za Zhi. 2014 Oct;39(20):3964-8. [2]. Teng CM, et al. Antiplatelet effects of some aporphine and phenanthrene alkaloids in rabbits and man. J Pharm Pharmacol. 1997 Jul;49(7):706-11. |
