LC3-mHTT-IN-AN1

• CAT Number: I017721
• CAS Number: 486443-73-6
• Molecular Formula: C₁₅H₉Br₂NO₃
• Molecular Weight: 411.04
• Purity: ≥95%
• Storage: 2-8°C
• IUPAC Name: (3Z)-5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-1H-indol-2-one
• InChI: InChI=1S/C15H9Br2NO3/c16-8-1-2-12-9(6-8)10(15(21)18-12)3-7-4-11(17)14(20)13(19)5-7/h1-6,19-20H,(H,18,21)/b10-3-
• InChIKey: GPKLWRHHVIBYEO-KMKOMSMNSA-N
• SMILES: C1=CC2=C(C=C1Br)C(=CC3=CC(=C(C(=C3)Br)O)O)C(=O)N2

LC3-mHTT-IN-AN1（Cat No.:I017721）, also known as Compound AN1, is a linker compound designed to interact with mutant huntingtin (mHTT) and LC3B proteins. It selectively binds to mHTT and LC3B, but not to the wild-type huntingtin protein (wtHTT) or unrelated control proteins. By targeting the mutant huntingtin protein, LC3-mHTT-IN-AN1 reduces the levels of mHTT in neurons of mice with Huntington’s disease (HD). This allele-selective reduction of mHTT offers potential therapeutic benefits in the treatment of Huntington’s disease.

Reference

[1]. Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Nov;575(7781):203-209.