For research use only. Not for therapeutic Use.
LC3-mHTT-IN-AN2 (Compound AN2) (Cat.No:I017720) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN2 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.
| Catalog Number | I017720 |
| CAS Number | 7758-73-8 |
| Molecular Formula | C₁₅H₁₀O₄ |
| Purity | ≥95% |
| Reference | [1]. Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Oct 30. |
