For research use only. Not for therapeutic Use.
LCB03-0110（Cat No.:I030583） is a potent angiogenesis inhibitor that acts by inhibiting VEGFR-2 (vascular endothelial growth factor receptor 2) and JAK/STAT3 (Janus kinase/signal transducer and activator of transcription 3) signaling pathways. It has demonstrated its efficacy in inhibiting angiogenesis, the process of new blood vessel formation, in both primary cultured human endothelial cells and cancer cells. By targeting these key pathways, LCB03-0110 shows potential as a therapeutic agent for diseases characterized by abnormal angiogenesis, such as cancer and certain vascular disorders.
| Catalog Number | I030583 |
| CAS Number | 1228102-01-9 |
| Synonyms | LCB03-0110; LCB030110; LCB03 0110 |
| Molecular Formula | C24H23N3O2S |
| Purity | 98% |
| Target | Src |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 3-(2-(3-(Morpholinomethyl)phenyl)thieno[3,2-b]pyridin-7-ylamino)phenol |
| InChI | InChI=1S/C24H23N3O2S/c28-20-6-2-5-19(14-20)26-21-7-8-25-22-15-23(30-24(21)22)18-4-1-3-17(13-18)16-27-9-11-29-12-10-27/h1-8,13-15,28H,9-12,16H2,(H,25,26) |
| InChIKey | ZCWXCBKGPJOAFQ-UHFFFAOYSA-N |
| SMILES | OC1=CC=CC(NC2=C3C(C=C(C4=CC=CC(CN5CCOCC5)=C4)S3)=NC=C2)=C1 |
| Reference | 1: Kim BH, Lee Y, Yoo H, Cui M, Lee S, Kim SY, Cho JU, Lee H, Yang BS, Kwon YG, Choi S, Kim TY. Anti-angiogenic activity of thienopyridine derivative LCB03-0110 by targeting VEGFR-2 and JAK/STAT3 Signalling. Exp Dermatol. 2015 Jul;24(7):503-9. doi: 10.1111/exd.12698. Epub 2015 Apr 27. PubMed PMID: 25808463. |
