LCS-1

• CAT Number: I030590
• CAS Number: 41931-13-9
• Molecular Formula: C11H8Cl2N2O
• Molecular Weight: 255.1
• Purity: 98%
• Synonyms: LCS-1, LCS1, LCS 1
• Target: Immunology/Inflammation
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: 2-8°C
• IUPAC Name: 4,5-dichloro-2-m-tolylpyridazin-3(2H)-one
• InChI: InChI=1S/C11H8Cl2N2O/c1-7-3-2-4-8(5-7)15-11(16)10(13)9(12)6-14-15/h2-6H,1H3
• InChIKey: SYUPLLHVMCLXEM-UHFFFAOYSA-N
• SMILES: O=C1C(Cl)=C(Cl)C=NN1C2=CC=CC(C)=C2

LCS-1（Cat No.:I030590） is a compound known as a superoxide dismutase 1 (SOD1) inhibitor. It has demonstrated the ability to inhibit the activation of the ERK and PI 3-kinase/AKT signaling pathways induced by serum. By inhibiting SOD1, LCS-1 potentially modulates cellular responses mediated by these signaling pathways. The ERK and PI 3-kinase/AKT pathways play crucial roles in various cellular processes, and their dysregulation has been implicated in several diseases.

Reference

1. R. Somwar et al. Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines. PNAS 2011, 108, 16375-16380.