LDC000067

• CAT Number: I000339
• CAS Number: 1073485-20-7
• Molecular Formula: C18H18N4O3S
• Molecular Weight: 370.43
• Purity: ≥95%
• Synonyms: (3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methanesulfonamide
• Target: Cyclin-Dependent Kinases
• Solubility: DMSO: ≥ 47 mg/mL
• Storage: under inert gas (nitrogen or Argon) at 2–8 °C
• IC50: 32.7 nM
• IUPAC Name: [3-[[6-(2-methoxyphenyl)pyrimidin-4-yl]amino]phenyl]methanesulfonamide
• InChI: InChI=1S/C18H18N4O3S/c1-25-17-8-3-2-7-15(17)16-10-18(21-12-20-16)22-14-6-4-5-13(9-14)11-26(19,23)24/h2-10,12H,11H2,1H3,(H2,19,23,24)(H,20,21,22)
• InChIKey: GGQCIOOSELPMBB-UHFFFAOYSA-N
• SMILES: COC1=CC=CC=C1C2=CC(=NC=N2)NC3=CC=CC(=C3)CS(=O)(=O)N

LDC000067 (Cat No.:I000339) is a potent and highly selective inhibitor of CDK9 (cyclin-dependent kinase 9) with an IC50 value of 44 nM. It exhibits significant selectivity for CDK9, with more than 55-fold, 125-fold, 210-fold, and over 227-fold selectivity over CDK2, CDK1, CDK4, and CDK6, respectively. It also shows greater than 227-fold selectivity over CDK7. By specifically targeting CDK9, LDC000067 has the potential to modulate transcriptional regulation and inhibit cell proliferation.

Reference

[1]. Albert TK, et al. Characterization of molecular and cellular functions of the cyclin-dependent kinase CDK9 using a novel specific inhibitor. Br J Pharmacol. 2014 Jan;171(1):55-68.