LDC1267

• CAT Number: I001392
• CAS Number: 1361030-48-9
• Molecular Formula: C30H26F2N4O5
• Molecular Weight: 560.56
• Purity: ≥95%
• Synonyms: N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide
• Target: TAM Receptor
• Solubility: DMSO: ≥ 42 mg/mL
• Storage: Store at -20°C
• IC50: <5 nM/8 nM/29 nM(Tyro3/Axl/Mer) [1]
• IUPAC Name: N-[4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-4-ethoxy-1-(4-fluoro-2-methylphenyl)pyrazole-3-carboxamide
• InChI: InChI=1S/C30H26F2N4O5/c1-5-40-28-16-36(23-8-6-18(31)12-17(23)2)35-29(28)30(37)34-19-7-9-25(21(32)13-19)41-24-10-11-33-22-15-27(39-4)26(38-3)14-20(22)24/h6-16H,5H2,1-4H3,(H,34,37)
• InChIKey: ISPBCAXOSOLFME-UHFFFAOYSA-N
• SMILES: CCOC1=CN(N=C1C(=O)NC2=CC(=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)F)C5=C(C=C(C=C5)F)C

LDC1267(CAT: I001392) is a potent and selective inhibitor of the TAM (Tyro3, Axl, and Mer) family of receptor tyrosine kinases, widely utilized in oncology and immunology research. By targeting these receptors, it blocks signaling pathways involved in tumor progression, metastasis, immune evasion, and apoptotic cell clearance. LDC1267 is particularly valuable for studying cancers with elevated TAM activity and for exploring its role in immune modulation and inflammation. Its high specificity and efficacy make it a critical tool for preclinical studies aimed at developing targeted therapies and understanding the TAM receptors’ functions in cancer and immune regulation.