LDC4297

• CAT Number: I013543
• CAS Number: 1453834-21-3
• Molecular Formula: C₂₃H₂₈N₈O
• Molecular Weight: 432.52
• Purity: ≥95%
• Target: CDK
• Solubility: DMSO: ≥60 mg/mL
• IUPAC Name: 2-piperidin-3-yloxy-8-propan-2-yl-N-[(2-pyrazol-1-ylphenyl)methyl]pyrazolo[1,5-a][1,3,5]triazin-4-amine
• InChI: InChI=1S/C23H28N8O/c1-16(2)19-15-27-31-21(19)28-23(32-18-8-5-10-24-14-18)29-22(31)25-13-17-7-3-4-9-20(17)30-12-6-11-26-30/h3-4,6-7,9,11-12,15-16,18,24H,5,8,10,13-14H2,1-2H3,(H,25,28,29)
• InChIKey: LSGRZENCFIIHNV-UHFFFAOYSA-N
• SMILES: CC(C)C1=C2N=C(N=C(N2N=C1)NCC3=CC=CC=C3N4C=CC=N4)OC5CCCNC5

LDC4297（Cat No.:I013543）is a potent and selective inhibitor of the bromodomain-containing protein BRD4, a key regulator of gene transcription involved in cancer and inflammation. By inhibiting BRD4, LDC4297 disrupts the interaction between BRD4 and acetylated histones, leading to reduced transcription of oncogenes and inflammatory mediators. This makes it valuable for research in oncology, especially in cancers like leukemia and solid tumors, where BRD4 plays a critical role in disease progression. LDC4297 also holds potential in studies of inflammatory and autoimmune diseases, offering insights into BRD4-related pathways.

Reference

[1]. Hutterer C, et al. A novel CDK7 inhibitor of the Pyrazolotriazine class exerts broad-spectrum antiviral activity at nanomolar concentrations. Antimicrob Agents Chemother. 2015 Apr;59(4):2062-71.