LDE-225 diphosphate

• CAT Number: I009555
• CAS Number: 1218778-77-8
• Molecular Formula: C₂₆H₃₂F₃N₃O₁₁P₂
• Molecular Weight: 681.49
• Purity: ≥95%
• Synonyms: LDE225; LDE 225; LDE-225; NVP-LDE225; NVP-LDE-225; NVP LDE225; Erismodegib; Sonidegib; Sonidegib phosphate; Odomzo.;N-(6-((2R,6S)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4′-(trifluoromethoxy)-[1,1′-biphenyl]-3-carboxamide bis(phosphate)
• Target: Smoothened
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• Related CAS: 956697-53-3(free base)
• IUPAC Name: N-[6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]pyridin-3-yl]-2-methyl-3-[4-(trifluoromethoxy)phenyl]benzamide;phosphoric acid
• InChI: InChI=1S/C26H26F3N3O3.2H3O4P/c1-16-14-32(15-17(2)34-16)24-12-9-20(13-30-24)31-25(33)23-6-4-5-22(18(23)3)19-7-10-21(11-8-19)35-26(27,28)29;2*1-5(2,3)4/h4-13,16-17H,14-15H2,1-3H3,(H,31,33);2*(H3,1,2,3,4)/t16-,17+
• InChIKey: RWIVSVMMGFFZIJ-VWDRLOGHSA-N
• SMILES: CC1CN(CC(O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F.OP(=O)(O)O.OP(=O)(O)O

LDE-225 diphosphate（Cat No.:I009555）, also known as Sonidegib, is a pharmacological compound that functions as a potent inhibitor of the Hedgehog signaling pathway. By targeting the Smoothened receptor, it effectively blocks the aberrant activation of this pathway. LDE-225 diphosphate has shown promise in the treatment of basal cell carcinoma (BCC) and has been evaluated in clinical trials. As a therapeutic agent, it offers the potential for inhibiting the growth and proliferation of cancer cells by interfering with the Hedgehog signaling pathway. LDE-225 diphosphate represents a valuable tool for research and development in the field of cancer therapeutics.