For research use only. Not for therapeutic Use.
LDHA-IN-3, as a selenobenzene compound, is a potent, noncompetitive lactate dehydrogenase (LDHA) inhibitor (IC50=145.2 nM). LDHA-IN-3 can be used for the research of cancer[1].
PSTMB (0~500 μM; 48 hours; MCF-7 cells) shows cytotoxic effect[1].
PSTMB (0.01~1 μM) shows dose-dependent inhibition of LDHA activity. PSTMB (0~0.5 μM) inhibits LDHA activity in Michaelis-Menten and Lineweaver-Burk plots. PSTMB (30 and 50 μM; HT29 cells) induces ROS production and mitochondrial damage[1].
PSTMB can bind to LDHA protein efficiently. PSTMB induces the intrinsic pathway-mediated apoptosis of cancer cells via production of mitochondrial ROS[1].
| Catalog Number | I044420 |
| CAS Number | 227010-33-5 |
| Synonyms | 1-phenylselanyl-4-(trifluoromethyl)benzene |
| Molecular Formula | C13H9F3Se |
| Purity | ≥95% |
| InChI | InChI=1S/C13H9F3Se/c14-13(15,16)10-6-8-12(9-7-10)17-11-4-2-1-3-5-11/h1-9H |
| InChIKey | WJNWVLLRQJFFTC-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)[Se]C2=CC=C(C=C2)C(F)(F)F |
| Reference | [1]. Kim EY, et al. A Novel Lactate Dehydrogenase Inhibitor, 1-(Phenylseleno)-4-(Trifluoromethyl) Benzene, Suppresses Tumor Growth through Apoptotic Cell Death. Sci Rep. 2019;9(1):3969. Published 2019 Mar 8. |
