For research use only. Not for therapeutic Use.
LDK378 dihydrochloride（Cat No.:I001469）, also known as lorlatinib, is a potent, selective inhibitor of anaplastic lymphoma kinase (ALK) and ROS1, two tyrosine kinases involved in the development of certain cancers, particularly non-small cell lung cancer (NSCLC). It works by inhibiting the abnormal signaling caused by mutations in these kinases, which can lead to tumor growth and metastasis. LDK378 dihydrochloride has shown significant clinical efficacy in ALK-positive NSCLC, especially in patients who have developed resistance to earlier ALK inhibitors. It is an important treatment option for targeted cancer therapy.
| Catalog Number | I001469 |
| CAS Number | 1380575-43-8 |
| Synonyms | 5-chloro-2-N-(5-methyl-4-piperidin-4-yl-2-propan-2-yloxyphenyl)-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine;dihydrochloride |
| Molecular Formula | C28H38Cl3N5O3S |
| Purity | ≥95% |
| Target | Anaplastic lymphoma kinase (ALK) |
| Solubility | H2O: ≥ 170 mg/mL |
| Storage | Store at -20°C |
| IC50 | 0.2 nM |
| IUPAC Name | 5-chloro-2-N-(5-methyl-4-piperidin-4-yl-2-propan-2-yloxyphenyl)-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine;dihydrochloride |
| InChI | InChI=1S/C28H36ClN5O3S.2ClH/c1-17(2)37-25-15-21(20-10-12-30-13-11-20)19(5)14-24(25)33-28-31-16-22(29)27(34-28)32-23-8-6-7-9-26(23)38(35,36)18(3)4;;/h6-9,14-18,20,30H,10-13H2,1-5H3,(H2,31,32,33,34);2*1H |
| InChIKey | WNCJOPLFICTLPT-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C(C=C1C2CCNCC2)OC(C)C)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)C(C)C)Cl.Cl.Cl |
