LDN-209929 2HCl

• CAT Number: I030602
• CAS Number: 1233355-57-1
• Molecular Formula: C17H19Cl3N2OS
• Molecular Weight: 405.76
• Purity: 98%
• Synonyms: LDN-209929 2HCl; LDN 209929 2HCl; LDN209929 2HCl; LDN-209929 dihydrochloride; LDN 209929 dihydrochloride; LDN209929 dihydrochloride
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 3-[(2-Chloro-7-methoxy-9-acridinyl)thio]-1-propanamine dihydrochloride
• InChI: InChI=1S/C17H17ClN2OS.2ClH/c1-21-12-4-6-16-14(10-12)17(22-8-2-7-19)13-9-11(18)3-5-15(13)20-16;;/h3-6,9-10H,2,7-8,19H2,1H3;2*1H
• InChIKey: WOCCOXNODBCCGK-UHFFFAOYSA-N
• SMILES: COC1=CC2=C(C=C1)N=C3C=CC(=CC3=C2SCCCN)C

LDN-209929 2HCl(CAT: I030602) is a potent and selective inhibitor of haspin kinase, a serine/threonine kinase responsible for phosphorylating histone H3 at threonine 3 (H3T3ph) during mitosis. This phosphorylation is critical for proper chromosome alignment and segregation. By inhibiting haspin, LDN-209929 disrupts chromosomal dynamics, leading to mitotic defects and potential cell cycle arrest. This mechanism makes it a valuable tool in cancer research and cell cycle studies, particularly for exploring targeted therapies aimed at impairing mitotic progression in rapidly dividing cancer cells. Its selectivity allows precise investigation of mitotic regulation and chromatin organization.