LDN-214117

• CAT Number: I002097
• CAS Number: 1627503-67-6
• Molecular Formula: C25H29N3O3
• Molecular Weight: 419.5
• Purity: ≥95%
• Synonyms: 1-(4-(6-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenyl)piperazine
• Target: TGF-β Receptor
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 22 nM(ALK2) [1]
• InChIKey: BHUXVRVMMYAXKN-UHFFFAOYSA-N

LDN-214117 (Cat.No:I002097) is a small molecule inhibitor that targets the transforming growth factor-beta (TGF-β) receptor type I kinase. It selectively inhibits TGF-β receptor activation, thereby blocking downstream signaling pathways involved in tumor growth and metastasis. LDN-214117 has shown potential as an anticancer agent and is being studied for its therapeutic applications in cancer treatment.

Reference

[1]. Mohedas AH, et al. Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. J Med Chem. 2014 Oct 9;57(19):7900-15.