LDN-57444

• CAT Number: I004517
• CAS Number: 668467-91-2
• Molecular Formula: C₁₇H₁₁Cl₃N₂O₃
• Molecular Weight: 397.64
• Purity: ≥95%
• Synonyms: [(Z)-[5-chloro-1-[(2,5-dichlorophenyl)methyl]-2-oxoindol-3-ylidene]amino] acetate
• Target: DUB
• Solubility: DMSO 16 mg/ml
• Storage: Desiccate at 4°C
• IC50: 0.4 uM(Ki)

LDN-57444 (Cat No.:I004517) is a potent inhibitor of the deubiquitinating enzyme UCHL1 (ubiquitin carboxyl-terminal hydrolase L1). It acts as a reversible and competitive inhibitor, binding to the active site of UCHL1. By inhibiting UCHL1, LDN-57444 disrupts the deubiquitination process, which plays a crucial role in protein degradation and cellular homeostasis. LDN-57444 has shown efficacy in preclinical studies and is being explored as a potential therapeutic agent for various diseases, including neurodegenerative disorders and cancer, where UCHL1 is involved in disease progression and pathogenesis.

Reference

[1]. Gong B, et al. Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory. Cell. 2006 Aug 25;126(4):775-88.
[2]. Tan YY, et al. Endoplasmic reticulum stress contributes to the cell death induced by UCH-L1 inhibitor. Mol Cell Biochem. 2008 Nov;318(1-2):109-15.