For research use only. Not for therapeutic Use.
Leflunomide (original brand name Arava) is an immunosuppressive disease-modifying antirheumatic drug (DMARD), used in active moderate-to-severe rheumatoid arthritis and psoriatic arthritis. It is a pyrimidine synthesis inhibitor that works by inhibiting dihydroorotate dehydrogenase.
| Catalog Number | A001130 |
| CAS Number | 75706-12-6 |
| Synonyms | HWA486 |
| Molecular Formula | C12H9F3N2O2 |
| Purity | ≥95% |
| Target | Nucleoside Antimetabolite/Analogue |
| Solubility | >13.5mg/mL in DMSO |
| Storage | 3 years -20C powder |
| InChIKey | VHOGYURTWQBHIL-UHFFFAOYSA-N |
| Reference | </br>1:Leflunomide – A human teratogen? A still not answered question. An evaluation of the German Embryotox pharmacovigilance database. Weber-Schoendorfer C, Beck E, Tissen-Diabaté T, Schaefer C.Reprod Toxicol. 2017 May 3;71:101-107. doi: 10.1016/j.reprotox.2017.04.007. [Epub ahead of print] PMID: 28478049 </br>2:Efficacy and safety of leflunomide as an adjuvant drug in refractory dermatomyositis with primarily cutaneous activity. de Souza RC, de Souza FHC, Miossi R, Shinjo SK.Clin Exp Rheumatol. 2017 Apr 18. [Epub ahead of print] PMID: 28422003 </br>3:Comparison of combined leflunomide and low-dose corticosteroid therapy with full-dose corticosteroid monotherapy for progressive IgA nephropathy. Min L, Wang Q, Cao L, Zhou W, Yuan J, Zhang M, Che X, Mou S, Fang W, Gu L, Zhu M, Wang L, Yu Z, Qian J, Ni Z.Oncotarget. 2017 Mar 22. doi: 10.18632/oncotarget.16468. [Epub ahead of print] PMID: 28415636 Free Article</br>4:Severe Bone Marrow Suppression Accompanying Pulmonary Infection and Hemorrhage of the Digestive Tract Associated with Leflunomide and Low-dose Methotrexate Combination Therapy. Qu C, Lu Y, Liu W.J Pharmacol Pharmacother. 2017 Jan-Mar;8(1):35-37. doi: 10.4103/jpp.JPP_93_16. PMID: 28405135 Free PMC Article</br>5:Inhibition of p70 S6 kinase (S6K1) activity by A77 1726, the active metabolite of leflunomide, induces autophagy through TAK1-mediated AMPK and JNK activation. Xu X, Sun J, Song R, Doscas ME, Williamson AJ, Zhou J, Sun J, Jiao X, Liu X, Li Y.Oncotarget. 2017 May 2;8(18):30438-30454. doi: 10.18632/oncotarget.16737. PMID: 28389629 Free Article</br>6:Leflunomide in the Treatment of a Pseudotumoral Genital Herpes Simplex Virus Infection in an HIV Patient. Roger MR, Anstead GM.Case Rep Infect Dis. 2017;2017:1589356. doi: 10.1155/2017/1589356. Epub 2017 Mar 8. PMID: 28373917 Free PMC Article</br>7:Leflunomide prevents ROS-induced systemic fibrosis in mice. Morin F, Kavian N, Chouzenoux S, Cerles O, Nicco C, Chéreau C, Batteux F.Free Radic Biol Med. 2017 Mar 30;108:192-203. doi: 10.1016/j.freeradbiomed.2017.03.035. [Epub ahead of print] PMID: 28365359 </br>8:Leflunomide for the treatment of trichodysplasia spinulosa in a liver transplant recipient. Kassar R, Chang J, Chan AW, Lilly LB, Al Habeeb A, Rotstein C.Transpl Infect Dis. 2017 Mar 22. doi: 10.1111/tid.12702. [Epub ahead of print] PMID: 28326649 </br>9:Combination therapy of leflunomide and glucocorticoids for the maintenance of remission in patients with IgG4-related disease: a retrospective study and literature review. Wang Y, Li K, Gao D, Luo G, Zhao Y, Wang X, Zhang J, Jin J, Zhao Z, Yang C, Zhu J, Zhang J, Huang F.Intern Med J. 2017 Mar 21. doi: 10.1111/imj.13430. [Epub ahead of print] PMID: 28321964 </br>10:Real-life experience of using conventional disease-modifying anti-rheumatic drugs (DMARDs) in psoriatic arthritis (PsA). Retrospective analysis of the efficacy of methotrexate, sulfasalazine, and leflunomide in PsA in comparison to spondyloarthritides other than PsA and literature review of the use of conventional DMARDs in PsA. Roussou E, Bouraoui A.Eur J Rheumatol. 2017 Mar;4(1):1-10. doi: 10.5152/eurjrheum.2017.1608. Epub 2017 Mar 1. PMID: 28293446 Free PMC Article |
