LEI-301

• CAT Number: I047664
• CAS Number: 2571585-09-4
• Molecular Formula: C25H25NO3
• Molecular Weight: 387.47
• Purity: ≥95%
• IUPAC Name: 2-oxo-N-[2-(4-phenoxyphenyl)ethyl]-5-phenylpentanamide
• InChI: InChI=1S/C25H25NO3/c27-24(13-7-10-20-8-3-1-4-9-20)25(28)26-19-18-21-14-16-23(17-15-21)29-22-11-5-2-6-12-22/h1-6,8-9,11-12,14-17H,7,10,13,18-19H2,(H,26,28)
• SMILES: C1=CC=C(C=C1)CCCC(=O)C(=O)NCCC2=CC=C(C=C2)OC3=CC=CC=C3

LEI-301 is a potent inhibitor for the PLAAT family members with pIC50 values of 7.3, 6.6, 7.3 and 7.4 for PLAAT2, PLAAT3, PLAAT4 and PLAAT5, respectively. LEI-301 was selective over the proteins of the endocannabinoid system (ECS). Moreover, LEI-301 reduced the NAE levels, including anandamide, in cells overexpressing PLAAT2 or PLAAT5.
KEYWORDS: LEI-301 | Supplier | PLAAT inhibitor | LEI301 | LEI 301 | CAS [2571585-09-4] | Phospholipid metabolism | Inhibitor | Enzymes | PLAAT | Phospholipase A and acyltransferase | LRAT | Lecithin retinol acyltransferase | NAPE | NAE

Reference

J Zhou et al. Structure-Activity Relationship Studies of α-Ketoamides as Inhibitors of the Phospholipase A and Acyltransferase Enzyme Family. J Med Chem. 2020 Sep 10;63(17):9340-9359.