Lenampicillin hydrochloride

• CAT Number: I004940
• CAS Number: 80734-02-7
• Molecular Formula: C21H24ClN3O7S
• Molecular Weight: 497.95
• Purity: ≥95%
• Target: Bacterial
• Storage: Store at -20°C
• IUPAC Name: (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl (2S,5R,6R)-6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;hydrochloride
• InChI: InChI=1S/C21H23N3O7S.ClH/c1-10-12(31-20(28)30-10)9-29-19(27)15-21(2,3)32-18-14(17(26)24(15)18)23-16(25)13(22)11-7-5-4-6-8-11;/h4-8,13-15,18H,9,22H2,1-3H3,(H,23,25);1H/t13-,14-,15+,18-;/m1./s1
• InChIKey: FXXSETTYJSGMCR-GLCLSGQWSA-N
• SMILES: CC1=C(OC(=O)O1)COC(=O)C2C(SC3N2C(=O)C3NC(=O)C(C4=CC=CC=C4)N)(C)C.Cl

Lenampicillin Hydrochloride（Cat No.:I004940）is an esterified prodrug of ampicillin, developed to enhance ampicillin’s absorption and bioavailability when administered orally. Once in the body, it is hydrolyzed to release active ampicillin, which works by inhibiting bacterial cell wall synthesis, effectively treating infections caused by gram-positive and some gram-negative bacteria. Lenampicillin Hydrochloride is used for respiratory, urinary, and gastrointestinal tract infections, offering a convenient oral dosing option for ampicillin-sensitive infections. Its improved pharmacokinetic profile enhances patient compliance and efficacy in outpatient settings, making it suitable for broader clinical use.

Reference

[1]. Awata N et al. [Metabolism of lenampicillin hydrochloride. II. Metabolism of promoiety]. Jpn J Antibiot. 1985 Jul;38(7):1785-93.

[2]. Awata N et al. [Metabolism of lenampicillin hydrochloride. I. Metabolism of ampicillin structure]. Jpn J Antibiot. 1985 Jul;38(7):1776-84.