Leonurine hydrochloride

• CAT Number: I002837
• CAS Number: 24735-18-0
• Molecular Formula: C14H22ClN3O5
• Molecular Weight: 347.79
• Purity: ≥95%
• Target: Autophagy
• Solubility: DMSO: ≥ 31 mg/mL
• Storage: Store at -20°C

Leonurine hydrochloride(CAT: I002837), also known as SCM-198, is a natural compound derived from the Chinese herb Leonurus japonicas. It possesses various pharmacological activities and has been studied for its potential therapeutic applications. Leonurine hydrochloride exhibits antioxidant properties and can scavenge free radicals, thereby protecting cells from oxidative stress. It also demonstrates anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines. Additionally, leonurine hydrochloride has been investigated for its cardiovascular benefits, including its ability to regulate blood pressure, improve cardiac function, and protect against ischemic heart injury. Furthermore, it shows neuroprotective effects by reducing neuronal damage and inflammation in various neurodegenerative diseases. Leonurine hydrochloride holds promise as a natural compound with multiple therapeutic potentials, although further research is needed to fully understand its mechanisms of action and clinical applications.

Reference

[1]. Mao F, et al. Leonurine hydrochloride induces apoptosis of H292 lung cancer cell by a mitochondria-dependent pathway. Pharm Biol. 2015;53(11):1684-90.
[2]. Yuan FL, et al. Leonurine hydrochloride inhibits osteoclastogenesis and prevents osteoporosis associated with estrogen deficiency by inhibiting the NF-κB and PI3K/Akt signaling pathways. Bone. 2015 Jun;75:128-37.
[3]. Li X, et al. Effect of leonurine hydrochloride on endothelin and the endothelin receptor-mediated signal pathway in medically-induced incomplete abortion in rats. Eur J Obstet Gynecol Reprod Biol. 2013 Jul;169(2):299-303.
[4]. Li X, et al. Effects of leonurine hydrochloride on medically induced incomplete abortion in early pregnancy rats. Eur J Obstet Gynecol Reprod Biol. 2011 Dec;159(2):375-80.