LEP(116-130)(mouse)

• CAT Number: I013088
• CAS Number: 258276-95-8
• Molecular Formula: C64H109N19O24S
• Molecular Weight: 1560.73
• Purity: ≥95%

LEP(116-130)(mouse) is a synthetic leptin peptide fragment.
LEP-(116-130) (300 µM) is unable to inhibit AP-OB binding[1].
LEP-(116-130) (1 mg, i.p.) results in a reduced rate of body weight gain in the presence of increased food intake compared with vehicle-injcted control mice. LEP-(116-130) significantly reduces blood glucose levels by appr 100 mg/dL. Administration of LEP-(116-130) to wild-type (+/+) C57BLKS/J-m mice for 4 or 7 days has no effect on their ability to thermoregulate[1].

Reference

[1]. Grasso P, et al. Inhibitory effects of leptin-related synthetic peptide 116-130 on food intake and body weight gain in female C57BL/6J ob/ob mice may not be mediated by peptide activation of the long isoform of the leptin receptor. Diabetes. 1999 Nov;48(11):2204-9.
 [Content Brief]