Leptomycin A

• CAT Number: R005985
• CAS Number: 87081-36-5
• Molecular Formula: C32H46O6
• Molecular Weight: 526.70
• Purity: ≥95%
• Synonyms: NSC 369326
• Target: Anti-infection
• Storage: -20°C
• IUPAC Name: (2E,10E,12E,16E,18E)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-19-(3-methyl-6-oxo-2,3-dihydropyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid
• InChI: 1S/C32H46O6/c1-20(16-22(3)12-14-28-24(5)13-15-30(35)38-28)10-9-11-21(2)17-25(6)31(36)27(8)32(37)26(7)18-23(4)19-29(33)34/h9,11-17,19-20,24-28,32,37H,10,18H2,1-8H3,(H,33,34)/b11-9+,14-12+,21-17+,22-16+,23-19+
• InChIKey: QECBVZBMGUAZDL-WRDLAOIUSA-N
• SMILES: CC1C=CC(=O)OC1/C=C/C(=C/C(C)C/C=C/C(=C/C(C)C(=O)C(C)C(C(C)C/C(=C/C(=O)O)/C)O)/C)/C

Leptomycin A (Cat.No:R005985) is a natural compound isolated from Streptomyces bacteria. It functions as a potent inhibitor of nuclear export by binding to exportin 1, a cellular protein involved in nucleocytoplasmic transport. Leptomycin A has been widely used in research to study cellular processes, particularly related to nuclear-cytoplasmic trafficking and cancer.