For research use only. Not for therapeutic Use.
Leptomycin A (Cat.No:R005985) is a natural compound isolated from Streptomyces bacteria. It functions as a potent inhibitor of nuclear export by binding to exportin 1, a cellular protein involved in nucleocytoplasmic transport. Leptomycin A has been widely used in research to study cellular processes, particularly related to nuclear-cytoplasmic trafficking and cancer.
| Catalog Number | R005985 |
| CAS Number | 87081-36-5 |
| Synonyms | NSC 369326 |
| Molecular Formula | C32H46O6 |
| Purity | ≥95% |
| Storage | -20°C |
| InChIKey | QECBVZBMGUAZDL-WRDLAOIUSA-N |
| Reference | Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization. Hamamoto T. et al. J Antibiot. 1983, 36, 639.<br/><br/>Leptomycins A and B, new antifungal antibiotics. II. Structure elucidation. Hamamoto T. et al. J Antibiot. 1983, 36, 646. <br/><br/>Leptomycin B, an inhibitor of the nuclear export receptor CRM1, inhibits COX-2 expression. Jang B.C. et al. J. Biol. Chem. 2003, 278, 2773.</span></p> |
