For research use only. Not for therapeutic Use.
Lepzacitinib(CAT: I040775) is an oral, selective Janus kinase 1 (JAK1) inhibitor developed for the treatment of autoimmune and inflammatory diseases. By selectively targeting JAK1, Lepzacitinib disrupts cytokine signaling pathways involved in immune cell activation and inflammation, particularly those mediated by interleukins and interferons. This results in the suppression of inflammatory responses while minimizing off-target effects associated with broader JAK inhibition. Lepzacitinib is being investigated for conditions such as atopic dermatitis, rheumatoid arthritis, and inflammatory bowel disease (IBD). It offers a promising therapeutic approach with the potential for improved efficacy and safety in JAK-targeted immunomodulatory therapy.
| CAS Number | 2321488-47-3 |
| Synonyms | ethyl 4-[[(3R)-1-(2-cyanoacetyl)piperidin-3-yl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxylate |
| Molecular Formula | C18H21N5O3 |
| Purity | ≥95% |
| IUPAC Name | ethyl 4-[[(3R)-1-(2-cyanoacetyl)piperidin-3-yl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxylate |
| InChI | InChI=1S/C18H21N5O3/c1-2-26-18(25)14-10-21-17-13(6-8-20-17)16(14)22-12-4-3-9-23(11-12)15(24)5-7-19/h6,8,10,12H,2-5,9,11H2,1H3,(H2,20,21,22)/t12-/m1/s1 |
| InChIKey | QQOPOYMFJLUSBI-GFCCVEGCSA-N |
| SMILES | CCOC(=O)C1=CN=C2C(=C1NC3CCCN(C3)C(=O)CC#N)C=CN2 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
