For research use only. Not for therapeutic Use.
Lesinurad sodium（Cat No.:I000561）, also known as RDEA594 sodium, is an oral medication that acts as a once-daily inhibitor of the URAT1 transporter. URAT1 is responsible for regulating the excretion of uric acid from the body through the kidneys. By inhibiting URAT1, lesinurad sodium helps to reduce serum uric acid levels, making it a useful treatment for hyperuricemia associated with gout.
| Catalog Number | I000561 |
| CAS Number | 1151516-14-1 |
| Molecular Formula | C17H13BrN3NaO2S |
| Purity | ≥95% |
| Target | URAT1 |
| Solubility | DMSO: ≥ 29 mg/mL |
| Storage | Store at -20°C |
| IUPAC Name | sodium;2-[[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate |
| InChI | InChI=1S/C17H14BrN3O2S.Na/c18-16-19-20-17(24-9-15(22)23)21(16)14-8-7-11(10-5-6-10)12-3-1-2-4-13(12)14;/h1-4,7-8,10H,5-6,9H2,(H,22,23);/q;+1/p-1 |
| InChIKey | FVYMVLTWIBGEMC-UHFFFAOYSA-M |
| SMILES | C1CC1C2=CC=C(C3=CC=CC=C23)N4C(=NN=C4Br)SCC(=O)[O-].[Na+] |
| Reference | <p style=/line-height:25px/> <br>[1]. L.yeh, B. Kerr, Z. Shen, RDEA594, A NOVEL URAT1 INHIBITOR, SHOWS SIGNIFICANT ADDITIVE URATE LOWERING EFFECTS IN COMBINATION WITH FEBUXOSTAT IN BOTH HEALTHY SUBJECTS AND GOUT PATIENTS. Clin.Pharmacol.Ther., 2011, 89, S92-3, Suppl. 1 <br>[2]. L.yeh, J. Yang, J. Theiss, RDEA594, a Potential Uric Acid Lowering Agent through Inhibition of Uric Acid Reuptake, Shows Better Pharmacokinetics than its Prodrug RDEA806 |
