Letrozole

• CAT Number: A001090
• CAS Number: 112809-51-5
• Molecular Formula: C17H11N5
• Molecular Weight: 285.31
• Purity: ≥95%
• Synonyms: CGS 20267
• Target: Autophagy
• Solubility: >14.3mg/mL in DMSO
• Storage: 3 years -20C powder
• IUPAC Name: 4-[(4-cyanophenyl)-(1,2,4-triazol-1-yl)methyl]benzonitrile
• InChI: InChI=1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H
• InChIKey: HPJKCIUCZWXJDR-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1C#N)C(C2=CC=C(C=C2)C#N)N3C=NC=N3

Letrozole(CAT: A001090) is a potent, non-steroidal aromatase inhibitor that selectively blocks the aromatase enzyme, which converts androgens into estrogens. By reducing estrogen production, Letrozole effectively suppresses estrogen-dependent tumor growth, making it a critical compound in oncology research, particularly in hormone receptor-positive breast cancer studies. It is also utilized to explore estrogen regulation in various biological processes and reproductive health research. Letrozole’s mechanism of action provides valuable insights into hormone-driven cancers and potential therapeutic strategies, supporting the development of targeted treatments aimed at minimizing estrogen-mediated disease progression.