Leu-AMS

• CAT Number: I013004
• CAS Number: 288591-93-5
• Molecular Formula: C₁₆H₂₅N₇O₇S
• Molecular Weight: 459.48
• Purity: ≥95%
• Target: Anti-infection
• Solubility: DMSO
• Storage: Store at -20°C
• IUPAC Name: [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl N-[(2S)-2-amino-4-methylpentanoyl]sulfamate
• InChI: InChI=1S/C16H25N7O7S/c1-7(2)3-8(17)15(26)22-31(27,28)29-4-9-11(24)12(25)16(30-9)23-6-21-10-13(18)19-5-20-14(10)23/h5-9,11-12,16,24-25H,3-4,17H2,1-2H3,(H,22,26)(H2,18,19,20)/t8-,9+,11+,12+,16+/m0/s1
• InChIKey: XFEDFDTWJLGMBO-LEJQEAHTSA-N
• SMILES: CC(C)C[C@@H](C(=O)NS(=O)(=O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)O)N

Leu-AMS（Cat No.:I013004）is a potent inhibitor of leucyl-tRNA synthetase (LeuRS), an enzyme involved in protein synthesis by attaching leucine to its corresponding tRNA. By inhibiting LeuRS, Leu-AMS disrupts the translation process, leading to impaired protein synthesis, making it a valuable compound in antimicrobial and cancer research. Its mechanism of action has garnered interest for the development of new antibiotics, particularly against drug-resistant bacteria. Additionally, Leu-AMS has shown potential in cancer therapy by selectively targeting rapidly dividing cells dependent on active protein synthesis.

Reference

[1]. Yoon S, et al. Discovery of Leucyladenylate Sulfamates as Novel Leucyl-tRNA Synthetase (LRS)-TargetedMammalian Target of Rapamycin Complex 1 (mTORC1) Inhibitors. J Med Chem. 2016 Nov 23;59(22):10322-10328.