For research use only. Not for therapeutic Use.
Leu-phalloidin（Cat No.:I030689）is a synthetic derivative of phalloidin, a cyclic peptide toxin originally isolated from the Amanita phalloides mushroom. It binds specifically to actin filaments, stabilizing the microfilament structure and preventing their depolymerization. This property makes Leu-phalloidin useful in laboratory research, particularly for studying the dynamics of the cytoskeleton in cells. It is commonly used in cell biology and microscopy to visualize actin filaments and study their role in cellular processes like division, migration, and signaling. However, due to its toxic nature, it is used with caution in experimental settings.
| Catalog Number | I030689 |
| CAS Number | 65986-99-4 |
| Synonyms | Leu-phalloidin; |
| Molecular Formula | C35H48N8O9S |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 18-hydroxy-34-(1-hydroxyethyl)-23,31-dimethyl-28-(2-methylpropyl)-12-thia-10,16,22,25,27,30,33,36-octazapentacyclo[12.11.11.03,11.04,9.016,20]hexatriaconta-3(11),4,6,8-tetraene-15,21,24,26,29,32,35-heptone |
| InChI | InChI=1S/C35H48N8O9S/c1-15(2)10-23-30(48)36-17(4)29(47)42-27(18(5)44)33(51)40-25-14-53-34-21(20-8-6-7-9-22(20)41-34)12-24(31(49)39-23)38-28(46)16(3)37-32(50)26-11-19(45)13-43(26)35(25)52/h6-9,15-19,23-27,41,44-45H,10-14H2,1-5H3,(H,36,48)(H,37,50)(H,38,46)(H,39,49)(H,40,51)(H,42,47) |
| InChIKey | DJCBRMHVPLXXAY-UHFFFAOYSA-N |
| SMILES | CC1C(=O)NC2CC3=C(NC4=CC=CC=C34)SCC(C(=O)N5CC(CC5C(=O)N1)O)NC(=O)C(NC(=O)C(NC(=O)C(NC2=O)CC(C)C)C)C(C)O |
