For research use only. Not for therapeutic Use.
Leucic acid ((S)-α-hydroxyisocaproic acid)（Cat No.:I014433） is a metabolite of branched-chain amino acid leucine, which plays an important role in the synthesis of muscle protein. Can be used as a tubulin inhibitor. If you need, please contact us in time, and we will reply to you as soon as possible within 24 hours.
| Catalog Number | I014433 |
| CAS Number | 13748-90-8 |
| Synonyms | Leucic acid, L-; EINECS 237-329-6;;(S)-2-hydroxy-4-methylpentanoic acid |
| Molecular Formula | C6H12O3 |
| Purity | ≥95% |
| Target | Endogenous Metabolite |
| Solubility | Soluble in DMSO |
| Storage | Room Temperature |
| IUPAC Name | (2S)-2-hydroxy-4-methylpentanoic acid |
| InChI | InChI=1S/C6H12O3/c1-4(2)3-5(7)6(8)9/h4-5,7H,3H2,1-2H3,(H,8,9)/t5-/m0/s1 |
| InChIKey | LVRFTAZAXQPQHI-YFKPBYRVSA-N |
| SMILES | CC(C)CC(C(=O)O)O |
| Reference | </br>1: Lee HS, Phat C, Choi SU, Lee C. Synergistic effect of a novel cyclic pentadepsipeptide, neoN-methylsansalvamide, and paclitaxel on human multidrug resistance cancer cell lines. Anticancer Drugs. 2013 Jun;24(5):455-60. doi: 10.1097/CAD.0b013e32835f060d. PubMed PMID: 23411682.</br>2: Lee HS, Lee C. Structural analysis of a new cytotoxic demethylated analogue of neo-N-methylsansalvamide with a different peptide sequence produced by Fusarium solani isolated from potato. J Agric Food Chem. 2012 May 2;60(17):4342-7. doi: 10.1021/jf205217v. Epub 2012 Apr 18. PubMed PMID: 22502643.</br>3: Chiou AJ, Ong GT, Wang KT, Chiou SH, Wu SH. Conformational study of two linear hexapeptides by two-dimensional NMR and computer-simulated modeling: implication for peptide cyclization in solution. Biochem Biophys Res Commun. 1996 Feb 15;219(2):572-9. PubMed PMID: 8605029.</br>4: Otsuka H, Floss HG. Steric course of the rhodium-catalyzed decarbonylation of chiral 4-methyl-[1-3H,2-2H1]pentanal. Z Naturforsch C. 1987 Apr;42(4):449-54. PubMed PMID: 2955591. </br> </br> |
