For research use only. Not for therapeutic Use.
Leukotriene A<sub>4</sub> (LTA<sub>4</sub>) is synthesized in mast cells, eosinophils, and neutrophils from arachidonic acid by 5-<wbr></wbr>lipoxygenase (5-<wbr></wbr>LO), which exhibits both lipoxygenase and LTA<sub>4</sub> synthase activities. LTA<sub>4</sub> is rapidly metabolized by LTA<sub>4</sub> hydrolase or LTC<sub>4</sub> synthase to LTB<sub>4</sub> or LTC<sub>4</sub>, respectively. LTA<sub>4</sub>, from leukocytes, is known to undergo transcellular metabolism in platelets, erythrocytes, and endothelial cells. Further metabolism of LTA<sub>4</sub> by 15-<wbr></wbr>LO leads to lipoxin biosynthesis. LTA<sub>4</sub> as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed.
| Catalog Number | R066692 |
| CAS Number | 73466-12-3 |
| Synonyms | LTA4 methyl ester |
| Molecular Formula | C21H32O3 |
| Purity | ≥95% |
| Storage | -80°C |
| IUPAC Name | methyl 4-[(2S,3S)-3-[(1E,3E,5Z,8Z)-tetradeca-1,3,5,8-tetraenyl]oxiran-2-yl]butanoate |
| InChI | InChI=1S/C21H32O3/c1-3-4-5-6-7-8-9-10-11-12-13-14-16-19-20(24-19)17-15-18-21(22)23-2/h7-8,10-14,16,19-20H,3-6,9,15,17-18H2,1-2H3/b8-7-,11-10-,13-12+,16-14+/t19-,20-/m0/s1 |
| InChIKey | WTKAVFHPLJFCMZ-NIBLXIPLSA-N |
| SMILES | CCCCCC=CCC=CC=CC=CC1C(O1)CCCC(=O)OC |
| Reference | 1.Shimizu, T.,Rådmark, O. and Samuelsson, B. Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 synthesis from arachidonic acid. Proceedings of the National Academy of Sciences of the United States of America 81, 689-693 (1984). |
