Leukotriene B4 dimethyl amide

• CAT Number: R066708
• CAS Number: 83024-92-4
• Molecular Formula: C22H37NO3
• Molecular Weight: 363.5
• Purity: ≥95%
• Synonyms: LTB4 dimethyl amide
• Storage: -20°C
• InChI: InChI=1S/C22H37NO3/c1-4-5-6-7-8-11-15-20(24)16-12-9-10-13-17-21(25)18-14-19-22(26)23(2)3/h8-13,16-17,20-21,24-25H,4-7,14-15,18-19H2,1-3H3/b10-9+,11-8-,16-12+,17-13-/t20-,21-/m1/s1
• InChIKey: BBJRTSLPWQUASB-UKODYPNASA-N
• SMILES: CCCCC/C=CC[C@@H](O)/C=C/C=CC=C[C@@H](O)CCCC(=O)N(C)C

LTB4 dimethyl amide（Cat. No.:R066708） is a moderate inhibitor of LTB4-induced degranulation of human neutrophils (Ki = 130 nM) and lysozyme release from rat PMNL. LTB4 dimethyl amide appears to be an antagonist of the LTB4 receptor on guinea pig lung membranes.

Reference

1.Showell, H.J.,Otterness, I.G.,Marfat, A., et al. Inhibition of leukotriene B4-induced neutrophil degranulation by leukotriene B4-dimethylamide. Biochemical and Biophysical Research Communications 106, 741-747 (1982).