For research use only. Not for therapeutic Use.
Leukotriene E<sub>4</sub> (LTE<sub>4</sub>) is produced by the action of dipeptidase on LTD<sub>4</sub>, leaving only the cysteinyl group still attached to the fatty acid backbone. It is one of the constituents of slow-<wbr></wbr>reacting substance of anaphylaxis (SRS-<wbr></wbr>A). LTE<sub>4</sub> is considerably less active (8 to 12-<wbr></wbr>fold) than LTC<sub>4</sub> in the biological activities characteristic of cysteinyl leukotrienes. Unlike LTC<sub>4</sub> and LTD<sub>4</sub>, LTE<sub>4</sub> accumulates in both plasma and urine. Therefore, urinary excretion of LTE<sub>4</sub> is most often used as an indicator of asthma. In humans, basal levels of LTE<sub>4</sub> range from 1-<wbr></wbr>100 pg/mg creatinine. In asthmatic patients, urinary LTE<sub>4</sub> levels increase to 80-<wbr></wbr>1,000 pg/mg creatinine.
| Catalog Number | R015471 |
| CAS Number | 75715-89-8 |
| Synonyms | LTE4 |
| Molecular Formula | C23H37NO5S |
| Purity | ≥95% |
| Target | Endogenous Metabolite |
| Storage | -80°C |
| IUPAC Name | (5S,6R,7E,9E,11Z,14Z)-6-[(2R)-2-amino-2-carboxyethyl]sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid |
| InChI | InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 |
| InChIKey | OTZRAYGBFWZKMX-FRFVZSDQSA-N |
| SMILES | CCCCCC=CCC=CC=CC=CC(C(CCCC(=O)O)O)SCC(C(=O)O)N |
| Reference | 1.Bernström, K., and Hammarström, S. Metabolism of leukotriene D by porcine kidney. The Journal of Biological Chemisty 256, 9579-9582 (1981). |
