Levamisole hydrochloride

For research use only. Not for therapeutic Use.

  • CAT Number: A000344
  • CAS Number: 16595-80-5
  • Molecular Formula: C11H13ClN2S
  • Molecular Weight: 240.75
  • Purity: ≥95%
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Levamisole Hydrochloride(Cat No.:A000344)is a synthetic imidazothiazole derivative used as an anthelmintic and immunomodulator. In veterinary medicine, it effectively treats parasitic infections caused by nematodes in livestock by acting as a cholinergic agonist, leading to neuromuscular paralysis and expulsion of the parasites. In humans, levamisole hydrochloride has been used as an adjunct therapy in cancer treatment, particularly colorectal cancer, due to its ability to stimulate the immune system by enhancing T-cell activity. Its dual role in parasitic control and immunomodulation makes it a versatile therapeutic agent.


Catalog Number A000344
CAS Number 16595-80-5
Synonyms

16595-80-5; Levamisole HCl; Ergamisol; Tramisol; Tramisole

Molecular Formula C11H13ClN2S
Purity ≥95%
Target Parasite
Overview of Clinical Research

Levamisole hydrochloride is an immunomodulator to treat Nephrotic syndrome.

IUPAC Name (6S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole;hydrochloride
InChI InChI=1S/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H/t10-;/m1./s1
InChIKey LAZPBGZRMVRFKY-HNCPQSOCSA-N
SMILES C1CSC2=N[C@H](CN21)C3=CC=CC=C3.Cl
Reference

1: Abdel-Aziz O, Hussien EM, El Kosasy AM, Ahmed N. Comparative Study of Univariate Spectrophotometry and Multivariate Calibration for the Determination of Levamisole Hydrochloride and Closantel Sodium in a Binary Mixture. J AOAC Int. 2016 Jul;99(4):941-7. doi: 10.5740/jaoacint.15-0252. Epub 2016 Jun 4. PubMed PMID: 27302698.<br />
2: Campos DM, Barbosa AP, Oliveira JA, Barbosa CA, Lobo TF, Silva LG, Thomaz DV, Peixoto Jde C. EVALUATION OF THE THERAPEUTIC EFFICACY OF LEVAMISOLE HYDROCHLORIDE ON THIRD-STAGE LARVAE OF Lagochilascaris minor IN EXPERIMENTALLY INFECTED MICE. Rev Inst Med Trop Sao Paulo. 2016;58:43. doi: 10.1590/S1678-9946201658043. Epub 2016 May 24. PubMed PMID: 27253745; PubMed Central PMCID: PMC4880000.<br />
3: Xu L, Luan F, Wang L, Liu H, Gao Y. Development of a capillary zone electrophoresis method for determination of mebendazole and levamisole hydrochloride in a combined tablet and a comparison with a LC method. J AOAC Int. 2014 Jan-Feb;97(1):128-32. PubMed PMID: 24672869.<br />
4: Maude RJ, Silamut K, Plewes K, Charunwatthana P, Ho M, Abul Faiz M, Rahman R, Hossain MA, Hassan MU, Bin Yunus E, Hoque G, Islam F, Ghose A, Hanson J, Schlatter J, Lacey R, Eastaugh A, Tarning J, Lee SJ, White NJ, Chotivanich K, Day NP, Dondorp AM. Randomized controlled trial of levamisole hydrochloride as adjunctive therapy in severe falciparum malaria with high parasitemia. J Infect Dis. 2014 Jan 1;209(1):120-9. doi: 10.1093/infdis/jit410. Epub 2013 Aug 13. PubMed PMID: 23943850; PubMed Central PMCID: PMC3864382.<br />
5: Wang H, Zhang J, Gao C, Zhu Y, Wang C, Zheng W. Topical levamisole hydrochloride therapy attenuates experimental murine allergic rhinitis. Eur J Pharmacol. 2007 Dec 22;577(1-3):162-9. Epub 2007 Aug 25. PubMed PMID: 17935711.<br />
6: Nogueira RB, Sakate M, Matsubara BB, de Souza Gon&ccedil;alves R, Magalh&atilde;es Rosa GJ. Evaluation of cardiac rhythm in dogs treated with levamisole hydrochloride using 24-hour ambulatory electrocardiography. J Vet Cardiol. 2003 Nov;5(2):29-32. doi: 10.1016/S1760-2734(06)70049-2. PubMed PMID: 19081362.<br />
7: Gallagher KM, Corrigan OI. Mechanistic aspects of the release of levamisole hydrochloride from biodegradable polymers. J Control Release. 2000 Nov 3;69(2):261-72. PubMed PMID: 11064133.<br />
8: Chartier C, Pors I, Sutra JF, Alvinerie M. Efficacy and pharmacokinetics of levamisole hydrochloride in goats with nematode infections. Vet Rec. 2000 Mar 18;146(12):350-1. PubMed PMID: 10777045.<br />
9: Du Preez JL, L&ouml;tter AP. Solid-phase extraction and HPLC determination of levamisole hydrochloride in sheep plasma. Onderstepoort J Vet Res. 1996 Sep;63(3):209-11. PubMed PMID: 8917857.<br />
10: Rai RB, Ahlawat SP, Singh S, Nagarajan V. Levamisole hydrochloride: an effective treatment for stephanofilarial dermatitis (humpsore) in cattle. Trop Anim Health Prod. 1994 Aug;26(3):175-6. PubMed PMID: 7809991.

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