For research use only. Not for therapeutic Use.
Levonadifloxacin arginine（Cat No.:I030721）is a novel antibiotic belonging to the fluoroquinolone class, developed to target bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and transcription in bacteria. It exhibits broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria, including multi-drug resistant strains. Levonadifloxacin arginine is primarily investigated for its potential in treating infections such as respiratory tract infections, skin infections, and urinary tract infections. It is known for its improved pharmacokinetics and efficacy compared to older fluoroquinolones. Clinical studies are ongoing to evaluate its safety, effectiveness, and optimal use in treating resistant bacterial infections.
| Catalog Number | I030721 |
| CAS Number | 306748-89-0 |
| Synonyms | Levonadifloxacin arginine salt; WCK 771; WCK-771; WCK771; |
| Molecular Formula | C25H35FN6O6 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | (2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid;(12S)-7-fluoro-8-(4-hydroxypiperidin-1-yl)-12-methyl-4-oxo-1-azatricyclo[7.3.1.05,13]trideca-2,5,7,9(13)-tetraene-3-carboxylic acid |
| InChI | InChI=1S/C19H21FN2O4.C6H14N4O2/c1-10-2-3-12-16-13(18(24)14(19(25)26)9-22(10)16)8-15(20)17(12)21-6-4-11(23)5-7-21;7-4(5(11)12)2-1-3-10-6(8)9/h8-11,23H,2-7H2,1H3,(H,25,26);4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t10-;4-/m00/s1 |
| InChIKey | WIFOPRFVQIVWTB-YBVIJTQESA-N |
| SMILES | C[C@H]1CCC2=C3N1C=C(C(=O)C3=CC(=C2N4CCC(CC4)O)F)C(=O)O.C(C[C@@H](C(=O)O)N)CN=C(N)N |
| Reference | 1: Rodvold KA, Gotfried MH, Chugh R, Gupta M, Yeole R, Patel A, Bhatia A. Intrapulmonary Pharmacokinetics of Levonadifloxacin following Oral Administration of Alalevonadifloxacin to Healthy Adult Subjects. Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e02297-17. doi: 10.1128/AAC.02297-17. Print 2018 Mar. PubMed PMID: 29263070; PubMed Central PMCID: PMC5826115. |
