Levopropoxyphene

• CAT Number: I030728
• CAS Number: 2338-37-6
• Molecular Formula: C22H29NO2
• Molecular Weight: 339.47
• Purity: 98%
• Synonyms: Levopropoxyphene; HSDB 3414; l-Propoxyphene; Levopropossifene
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (2R,3S)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl propionate
• InChI: InChI=1S/C22H29NO2/c1-5-21(24)25-22(18(2)17-23(3)4,20-14-10-7-11-15-20)16-19-12-8-6-9-13-19/h6-15,18H,5,16-17H2,1-4H3/t18-,22+/m0/s1
• InChIKey: XLMALTXPSGQGBX-PGRDOPGGSA-N
• SMILES: C[C@H]([C@](C1=CC=CC=C1)(OC(CC)=O)CC2=CC=CC=C2)CN(C)C

Levopropoxyphene (Cat.No:I030728), also known as levo-Dromoran, is an opioid analgesic medication used for the relief of moderate to severe pain. It acts by binding to opioid receptors in the central nervous system, thereby reducing pain perception. Levopropoxyphene should be used with caution due to its potential for abuse, addiction, and respiratory depression.

Reference

1: SCHVARTSMAN S. [POISONING BY INGESTION OF AN EXCESSIVE DOSE OF LEVOPROPOXYPHENE (LETUSIN)]. Pediatr Prat. 1964;35:51-2. Portuguese. PubMed PMID: 14254473.
2: CLARKE EG. A NOTE ON THE DIFFERENTIATION BETWEEN DEXTRO- AND LAEVOPROPOXYPHENE. J Pharm Pharmacol. 1963 Sep;15:624-5. PubMed PMID: 14059611.
3: McMahon RE, Sullivan HR. Reduction of levopropoxyphene N-oxide to propoxyphene by dogs in vivo and rat liver microsomal fraction in vitro. Xenobiotica. 1977 Jun;7(6):377-82. PubMed PMID: 610054.
4: Wainer IW. Three-dimensional view of pharmacology. Am J Hosp Pharm. 1992 Sep;49(9 Suppl 1):S4-8. Review. Erratum in: Am J Hosp Pharm 1992 Dec;49(12):2929. PubMed PMID: 1530004.
5: Craviso GL, Musacchio JM. High-affinity dextromethorphan binding sites in guinea pig brain. II. Competition experiments. Mol Pharmacol. 1983 May;23(3):629-40. PubMed PMID: 6865909.