Levosimendan

• CAT Number: A000693
• CAS Number: 141505-33-1
• Molecular Formula: C14H12N6O
• Molecular Weight: 280.3
• Purity: ≥95%
• Synonyms: 141505-33-1; Simdax; (R)-Simendan; Levosimendan [INN]; Levosimendanum
• Target: Phosphodiesterase Inhibitor
• Storage: -20°C
• InChI: 1S/C14H12N6O/c1-9-6-13(21)19-20-14(9)10-2-4-11(5-3-10)17-18-12(7-15)8-16/h2-5,9,17H,6H2,1H3,(H,19,21)/t9-/m1/s1
• InChIKey: WHXMKTBCFHIYNQ-SECBINFHSA-N
• SMILES: CC1CC(=O)NN=C1C2=CC=C(C=C2)NN=C(C#N)C#N

Levosimendan is a calcium sensitizer that can cause increased cardiac contractility by binding troponin C, promotes vasodilation by activating ATP-sensitive potassium channels on vascular smooth muscle cells, and performs a cardioprotective function by prompting the opening of mitochondrial potassium channels in cardiomyocytes. It also has been reported to inhibit phosphodiesterases 3 and 4 in left ventricular cardiac tissue.

Reference

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