Levulinic acid-d5

• CAT Number: R060978
• CAS Number: 1206185-52-5
• Molecular Formula: C5H3D5O3
• Molecular Weight: 121.15
• Purity: ≥95%
• Synonyms: 3,3,5,5,5-pentadeuterio-4-oxopentanoic acid
• InChI: InChI=1S/C5H8O3/c1-4(6)2-3-5(7)8/h2-3H2,1H3,(H,7,8)/i1D3,2D2
• InChIKey: JOOXCMJARBKPKM-ZBJDZAJPSA-N
• SMILES: CC(=O)CCC(=O)O

Levulinic acid-d5 is the deuterium labeled Levulinic acid[1]. Levulinic acid is a precursor for the synthesis of biofuels, such as ethyl levulinate[2].
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Reference

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
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[2]. Pileidis FD, et al. Levulinic Acid Biorefineries: New Challenges for Efficient Utilization of Biomass. ChemSusChem. 2016 Mar 21;9(6):562-82.
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