Lexithromycin

• CAT Number: R006465
• CAS Number: 53066-26-5
• Molecular Formula: C38H70N2O13
• Molecular Weight: 763.00
• Purity: ≥95%
• Synonyms: erythromycin, 9-(O-methyloxime)
• Target: Bacterial
• Storage: -20°C
• IUPAC Name: (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-10-methoxyimino-3,5,7,9,11,13-hexamethyl-oxacyclotetradecan-2-one
• InChI: InChI=1S/C38H70N2O13/c1-15-26-38(10,46)31(42)21(4)28(39-48-14)19(2)17-36(8,45)33(53-35-29(41)25(40(11)12)16-20(3)49-35)22(5)30(23(6)34(44)51-26)52-27-18-37(9,47-13)32(43)24(7)50-27/h19-27,29-33,35,41-43,45-46H,15-18H2,1-14H3/b39-28+/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1
• InChIKey: HPZGUSZNXKOMCQ-SQYJNGITSA-N
• SMILES: CC[C@@H]1[C@@]([C@@H]([C@H](/C(=N/OC)/[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)O)(C)O

Lexithromycin（Cat No.:R006465）is a macrolide antibiotic known for its activity against a variety of Gram-positive bacteria, particularly respiratory pathogens. It works by inhibiting bacterial protein synthesis through binding to the 50S ribosomal subunit, preventing bacterial growth and replication. Lexithromycin is primarily studied for its potential to treat respiratory infections, including bronchitis and pneumonia. Its pharmacokinetic properties, such as high tissue penetration and a favorable safety profile, make it a promising option for respiratory care. Research continues to evaluate its effectiveness against resistant bacterial strains.

Reference

9-Substituted erythromycin A and B oximes. Von Esch A.M. 1972 US Patent 3,681,326.