For research use only. Not for therapeutic Use.
LG100754 (CAT: M128491) is a selective retinoid X receptor (RXR) modulator with unique dimer-specific activity. It acts as an antagonist of RXR:RXR homodimers, while functioning as an agonist of RXR:PPARα and RXR:PPARγ heterodimers, thereby selectively activating endogenous RXR heterodimers. LG100754 exhibits strong insulin-sensitizing effects, improving TNFα-mediated insulin resistance in mature adipocytes and regulating insulin-dependent signaling pathways. In vivo, oral administration of LG100754 (100 mg/kg) blocks glucose elevation, confirming its antidiabetic potential. With its dual role as a modulator of RXR dimerization and regulator of metabolic signaling, LG100754 is a valuable tool for metabolic disease and diabetes research.
| CAS Number | 180713-37-5 |
| Molecular Formula | C26H36O3 |
| Purity | ≥95% |
| IUPAC Name | (2E,4E,6Z)-3-methyl-7-(5,5,8,8-tetramethyl-3-propoxy-6,7-dihydronaphthalen-2-yl)octa-2,4,6-trienoic acid |
| InChI | InChI=1S/C26H36O3/c1-8-14-29-23-17-22-21(25(4,5)12-13-26(22,6)7)16-20(23)19(3)11-9-10-18(2)15-24(27)28/h9-11,15-17H,8,12-14H2,1-7H3,(H,27,28)/b10-9+,18-15+,19-11- |
| InChIKey | HNODNXQAYXJFMQ-LQUSFLDPSA-N |
| SMILES | CCCOC1=CC2=C(C=C1/C(=C\C=C\C(=C\C(=O)O)\C)/C)C(CCC2(C)C)(C)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
