LG100754

• CAT Number: M128491
• CAS Number: 180713-37-5
• Molecular Formula: C26H36O3
• Molecular Weight: 396.56
• Purity: ≥95%

LG100754 (UVI 2112) is a RXR dimers modulater. LG100754 acts as a RXR:RXR homodimer antagonist, but functions as a agonist towards RXR:PPARα and RXR:PPARγ heterodimers. LG100754 is an insulin sensitizer that functions through RXR[1].
LG100754 is a selective activator of endogenous RXR heterodimers[1].
LG100754 can also improve TNFα-mediated insulin resistance in mature adipocytes[1].
LG100754 acts as a bona fide activator of endogenous RXR:PPARγ heterodimers and regulator of insulin-dependent signaling pathways[1].
LG100754 (100 mg/kg) completely blocks the increase in glucose levels, suggesting that LG100754 can improve insulin resistance in vivo[1].

Reference

[1]. Cesario RM, et al. The rexinoid LG100754 is a novel RXR:PPARgamma agonist and decreases glucose levels in vivo. Mol Endocrinol. 2001 Aug;15(8):1360-9.
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