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1210416-93-5-LGB-321 HCl LGB-321 HCl

LGB-321 HCl

For research use only. Not for therapeutic Use.

  • CAT Number: I007662
  • CAS Number: 1210416-93-5
  • Molecular Formula: C23H24Cl2F3N5O2
  • Molecular Weight: 530.37
  • Purity: ≥95%
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LGB-321 (Cat.No:I007662) is a potent and selective ATP-competitive small molecule inhibitor of PIM kinases (Pan-PIM kinase inhibitor). LGB321 is unique relative to previously described PIM inhibitors, in that it is active in PIM2 dependent cell lines. , a kinase that has proven difficult to inhibit in the cellular context. Consistent with its activity on all three PIM kinases, LGB321 inhibits proliferation of a number of cell lines derived from diverse hematological malignancies, including MM, AML, CML and B-Cell NHL. In vivo, LGB-321 is orally available, demonstrates efficacy in tumor xenografts and is well-tolerated within the therapeutic exposure range in mice. 


Catalog Number I007662
CAS Number 1210416-93-5
Synonyms

LGB321; LGB-321; LGB 321; LGB321 HCl;N-(4-((3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide dihydrochloride

Molecular Formula C23H24Cl2F3N5O2
Purity ≥95%
Target Pan-PIM inhibitor
Solubility Soluble in DMSO, not in water
Storage 0 - 4°C for short term , or -20°C for long term.
Related CAS 1469925-36-7(hydrochloride     1:1); 1210417-75-6(free base)    
SMILES O=C(NC1=C(N2C[C@@H](N)[C@H](O)[C@@H](C)C2)C=CN=C1)C3=NC(C4=C(F)C=CC=C4F)=C(F)C=C3.[H]Cl.[H]Cl
Reference

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2:Olive (Olea europaea) leaf methanolic extract prevents HCl/ethanol-induced gastritis in rats by attenuating inflammation and augmenting antioxidant enzyme activities. Al-Quraishy S, Othman MS, Dkhil MA, Abdel Moneim AE.Biomed Pharmacother. 2017 Apr 29;91:338-349. doi: 10.1016/j.biopha.2017.04.069. [Epub ahead of print] PMID: 28463797 <br />
3:HCl dissociating on a rigid Au(111) surface: A six-dimensional quantum mechanical study on a new potential energy surface based on the RPBE functional. Liu T, Fu B, Zhang DH.J Chem Phys. 2017 Apr 28;146(16):164706. doi: 10.1063/1.4982051. PMID: 28456190 <br />
4:A new ab initio potential energy surface of LiClH (1A/’) system and quantum dynamics calculation for Li + HCl (v = 0, j = 0-2) → LiCl + H reaction. Tan RS, Zhai HC, Yan W, Gao F, Lin SY.J Chem Phys. 2017 Apr 28;146(16):164305. doi: 10.1063/1.4982066. PMID: 28456188 <br />
5:Spectroscopic Characterization of the Reaction Products between the Criegee Intermediate CH<sub>2</sub> OO and HCl. Cabezas C, Endo Y.Chemphyschem. 2017 Apr 27. doi: 10.1002/cphc.201700446. [Epub ahead of print] PMID: 28449411 <br />
6:Formulation, release characteristics, and bioavailability study of gastroretentive floating matrix tablet and floating raft system of Mebeverine HCl. El Nabarawi MA, Teaima MH, Abd El-Monem RA, El Nabarawy NA, Gaber DA.Drug Des Devel Ther. 2017 Apr 3;11:1081-1093. doi: 10.2147/DDDT.S131936. eCollection 2017. PMID: 28435220 Free PMC Article<br />
7:Lipids bearing extruded-spheronized pellets for extended release of poorly soluble antiemetic agent-Meclizine HCl. Qazi F, Shoaib MH, Yousuf RI, Nasiri MI, Ahmed K, Ahmad M.Lipids Health Dis. 2017 Apr 12;16(1):75. doi: 10.1186/s12944-017-0466-x. PMID: 28403892 Free PMC Article<br />
8:Acute exposure of primary rat soleus muscle to zilpaterol HCl (β2 adrenergic agonist), TNFα, or IL-6 in culture increases glucose oxidation rates independent of the impact on insulin signaling or glucose uptake. Cadaret CN, Beede KA, Riley HE, Yates DT.Cytokine. 2017 Apr 5;96:107-113. doi: 10.1016/j.cyto.2017.03.014. [Epub ahead of print] PMID: 28390265 <br />
9:Effects of anabolic implants and ractopamine-HCl on muscle fiber morphometrics, collagen solubility, and tenderness of beef longissimus lumborum steaks. Ebarb SM, Phelps KJ, Drouillard JS, Maddock-Carlin KR, Vaughn MA, Burnett DD, Noel JA, Van Bibber-Krueger CL, Paulk CB, Grieger DM, Gonzalez JM.J Anim Sci. 2017 Mar;95(3):1219-1231. doi: 10.2527/jas.2016.1263. PMID: 28380530 <br />
10:Comparative plasma and tissue distribution of Sun Pharma/’s generic doxorubicin HCl liposome injection versus Caelyx<sup>&#174;</sup> (doxorubicin HCl liposome injection) in syngeneic fibrosarcoma-bearing BALB/c mice and Sprague-Dawley rats. Burade V, Bhowmick S, Maiti K, Zalawadia R, Jain D, Rajamannar T.Cancer Chemother Pharmacol. 2017 May;79(5):899-913. doi: 10.1007/s00280-017-3278-9. Epub 2017 Mar 27. PMID: 28349166 Free PMC Article

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