LGD-2226

For research use only. Not for therapeutic Use.

  • CAT Number: R036606
  • CAS Number: 328947-93-9
  • Molecular Formula: C14H9F9N2O
  • Molecular Weight: 392.225
  • Purity: ≥95%
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LGD-2226(CAT: R036606) is a derivative of quinolinone. As an oral selective androgen receptor agonist, LGD-2226 has anabolic effects in both muscle and bone tissue and is currently used to treat diseases such as muscle atrophy and osteoporosis. This product is used in organic synthesis, pharmaceutical research and development, and other scientific research fields.


Catalog Number R036606
CAS Number 328947-93-9
Synonyms

6-[Bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-2(1H)-quinolinone;

Molecular Formula C14H9F9N2O
Purity ≥95%
Target androgen receptor modulator
Storage -20°C
IUPAC Name 6-[bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-1H-quinolin-2-one
InChI InChI=1S/C14H9F9N2O/c15-12(16,17)5-25(6-13(18,19)20)7-1-2-10-8(3-7)9(14(21,22)23)4-11(26)24-10/h1-4H,5-6H2,(H,24,26)
InChIKey ULBPQWIGZUGPHU-UHFFFAOYSA-N
SMILES C1=CC2=C(C=C1N(CC(F)(F)F)CC(F)(F)F)C(=CC(=O)N2)C(F)(F)F
Reference

<br />
1: Hong MH, Sun H, Jin CH, Chapman M, Hu J, Chang W, Burnett K, Rosen J,<br />
Negro-Vilar A, Miner JN. Cell-specific activation of the human skeletal<br />
alpha-actin by androgens. Endocrinology. 2008 Mar;149(3):1103-12. Epub 2007 Dec<br />
6. PubMed PMID: 18063690.<br />
2: Thevis M, Kohler M, Maurer J, Schl&ouml;rer N, Kamber M, Sch&auml;nzer W. Screening for<br />
2-quinolinone-derived selective androgen receptor agonists in doping control<br />
analysis. Rapid Commun Mass Spectrom. 2007;21(21):3477-86. PubMed PMID: 17985352.<br />
3: van Oeveren A, Motamedi M, Mani NS, Marschke KB, L&oacute;pez FJ, Schrader WT,<br />
Negro-Vilar A, Zhi L. Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino-<br />
4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor<br />
modulator. J Med Chem. 2006 Oct 19;49(21):6143-6. PubMed PMID: 17034117.<br />
4: Miner JN, Chang W, Chapman MS, Finn PD, Hong MH, L&oacute;pez FJ, Marschke KB, Rosen<br />
J, Schrader W, Turner R, van Oeveren A, Viveros H, Zhi L, Negro-Vilar A. An<br />
orally active selective androgen receptor modulator is efficacious on bone,<br />
muscle, and sex function with reduced impact on prostate. Endocrinology. 2007<br />
Jan;148(1):363-73. Epub 2006 Oct 5. PubMed PMID: 17023534.<br />
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