LGK974

• CAT Number: I000965
• CAS Number: 1243244-14-5
• Molecular Formula: C₂₃H₂₀N₆O
• Molecular Weight: 396.44
• Purity: ≥95%
• Synonyms: 2-[5-methyl-6-(2-methylpyridin-4-yl)pyridin-3-yl]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide
• Target: Porcupine
• Solubility: DMSO: ≥ 36 mg/mL
• Storage: Store at -20 C
• IC50: 0.4 nM [1]
• InChI: InChI=1S/C23H20N6O/c1-15-9-17(12-28-23(15)18-5-6-25-16(2)10-18)11-22(30)29-21-4-3-19(13-27-21)20-14-24-7-8-26-20/h3-10,12-14H,11H2,1-2H3,(H,27,29,30)
• InChIKey: XXYGTCZJJLTAGH-UHFFFAOYSA-N
• SMILES: CC1=C(N=CC(=C1)CC(=O)NC2=NC=C(C=C2)C3=NC=CN=C3)C4=CC(=NC=C4)C

LGK974(CAT: I000965) is a potent and selective inhibitor of porcupine (PORCN), a key enzyme involved in Wnt signaling. By blocking the secretion of Wnt ligands, it effectively disrupts Wnt/β-catenin signaling pathways, which play a critical role in cancer progression and stem cell regulation. This high-purity compound is widely used in preclinical research to study Wnt-related mechanisms and their therapeutic implications in oncology and regenerative medicine. Suitable for in vitro and in vivo studies, LGK974 provides researchers with a reliable tool to investigate Wnt signaling dynamics and develop innovative therapeutic strategies targeting this pathway.